Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

We tested the role of different intracellular proteolytic pathways in sepsis-induced muscle proteolysis. Sepsis was induced in rats by cecal ligation and puncture; controls were sham operated. Total and myofibrillar proteolysis was determined in incubated extensor digitorum longus muscles as release...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Tiao, G, Fagan, J M, Samuels, N, James, J H, Hudson, K, Lieberman, M, Fischer, J E, Hasselgren, P O
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330052/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7989581/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117588
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