Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules.

Recent data indicate that megakaryocyte/platelet alpha-granule fibrinogen is endocytosed from plasma. Because fibrinogen is the major platelet protein present in high concentrations in alpha-granules, fibrinogen uptake into alpha-granules may occur via specific receptors. In that cells of the megaka...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Handagama, P, Bainton, D F, Jacques, Y, Conn, M T, Lazarus, R A, Shuman, M A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330014/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8423218/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116170
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