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Point mutations in the West Nile virus RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo
The West Nile virus (WNV) genome contains a single RNA-dependent RNA polymerase (RdRp) gene, which is responsible for replication of the viral genome and, as such, is an important target for antiviral therapy. Viral RdRps are known to lack proofreading capabilities and as a result viruses such as WN...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3299857/ https://ncbi.nlm.nih.gov/pubmed/22365326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.01.036 |
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