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XIAP mono-ubiquitylates Groucho/TLE to promote canonical Wnt signaling
A key event in Wnt signaling is conversion of TCF/Lef from a transcriptional repressor to an activator, yet how this switch occurs is not well understood. Here, we report an unanticipated role for X-linked Inhibitor of Apoptosis (XIAP) in regulating this critical Wnt signaling event that is independ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3299836/ https://ncbi.nlm.nih.gov/pubmed/22304967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.12.032 |
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