Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy

Subunit 7a of mouse cytochrome c oxidase (Cox) displays a contractile muscle-specific isoform, Cox7a1, that is the major cardiac form. To gain insight into the role of this isoform, we have produced a new knockout mouse line that lacks Cox7a1. We show that homozygous and heterozygous Cox7a1 knockout...

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Main Authors: Hüttemann, Maik, Klewer, Scott, Lee, Icksoo, Pecinova, Alena, Pecina, Petr, Liu, Jenney, Lee, Michael, Doan, Jeffrey W., Larson, Douglas, Slack, Elise, Maghsoodi, Bita, Erickson, Robert P., Grossman, Lawrence I.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299818/
https://ncbi.nlm.nih.gov/pubmed/22119795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2011.11.002
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