RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI(3) Kinase/Akt Signaling Pathways

Musashi1 (MSI1) is an RNA-binding protein that plays critical roles in nervous-system development and stem-cell self-renewal. Here, we examined its role in the progression of glioma. Short hairpin RNA (shRNA)-based MSI1-knock down (KD) in glioblastoma and medulloblastoma cells resulted in a signific...

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Autors principals: Muto, Jun, Imai, Takao, Ogawa, Daisuke, Nishimoto, Yoshinori, Okada, Yohei, Mabuchi, Yo, Kawase, Takeshi, Iwanami, Akio, Mischel, Paul S., Saya, Hideyuki, Yoshida, Kazunari, Matsuzaki, Yumi, Okano, Hideyuki
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299785/
https://ncbi.nlm.nih.gov/pubmed/22428049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033431
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