Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.

Complementary DNA cloning of the 130-kD pemphigus vulgaris (PV) autoantigen (PVA) has indicated that it is a member of the cadherin family of Ca(2+)-dependent cell adhesion molecules. By homology with typical cadherins, PVA has five extracellular domains (EC1 through EC5). To localize immunogenic do...

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Pubblicato in:	J Clin Invest
Autori principali:	Amagai, M, Karpati, S, Prussick, R, Klaus-Kovtun, V, Stanley, J R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329947/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1522242/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115968
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