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Preparation, Characterization, and In Vitro Intestinal Permeability Evaluation of Thalidomide–Hydroxypropyl-β-Cyclodextrin Complexes

Thalidomide is emerging as a therapeutic agent with renewed clinical importance, presenting anti-inflammatory, immunomodulatory, and antineoplasic properties. In this work, we studied the complexation of thalidomide with cyclodextrins as a strategy to circumvent the poor aqueous solubility of the dr...

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Detalhes bibliográficos
Main Authors: Kratz, Jadel M., Teixeira, Marina R., Ferronato, Karine, Teixeira, Helder F., Koester, Letícia S., Simões, Cláudia M. O.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299449/
https://ncbi.nlm.nih.gov/pubmed/22160886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-011-9739-2
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