AVE0991, a Nonpeptide Compound, Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation via Induction of Heme Oxygenase-1 and Downregulation of p-38 MAPK Phosphorylation

The nonpeptide AVE0991 is an agonist of the angiotensin-(1–7) (Ang-(1–7)) Mas receptor and is expected to be a putative new drug for treatment of cardiovascular disease. However, the mechanisms involved in the antiproliferative effects of AVE0991 are not fully understood. We saw that the compound at...

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Bibliographische Detailangaben
Hauptverfasser: Sheng-Long, Chen, Yan-Xin, Wu, Yi-Yi, Huang, Ming, Fang, Jian-Gui, He, Yi-Li, Chen, Wen-Jing, Xia, Hong, Ma
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299313/
https://ncbi.nlm.nih.gov/pubmed/22518299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/958298
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