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Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase.

To characterize the nature of thyroid peroxidase (TPO) autoantibodies present in the sera of patients with autoimmune thyroid disease, we cloned three IgG1/kappa Fab fragments which bind 125I-TPO. This was accomplished by the molecular cloning and expression in bacteria of IgG gene fragments from B...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Portolano, S, Chazenbalk, G D, Seto, P, Hutchison, J S, Rapoport, B, McLachlan, S M
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 1992
Aiheet:
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329922/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1381722/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115943
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