Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity

Toll-like receptors (TLRs) shape innate and adaptive immunity to microorganisms. The enzyme IRAK1 transduces signals from TLRs, but its activation and regulation mechanisms remain unknown. We show that TLR7 and TLR9 activated the isomerase Pin1, which then bound to IRAK1, resulting in IRAK1 activati...

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Detalhes bibliográficos
Main Authors: Tun-Kyi, Adrian, Finn, Greg, Greenwood, Alex, Nowak, Michael, Lee, Tae Ho, Asara, John M., Tsokos, George C., Fitzgerald, Kate, Israel, Elliot, Li, Xiaoxia, Exley, Mark, Nicholson, Linda K., Lu, Kun Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298750/
https://ncbi.nlm.nih.gov/pubmed/21743479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2069
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