Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

Imipramine is the prototypic tricyclic antidepressant utilized in the treatment of major depression and exerts its therapeutic efficacy only after prolonged administration. We report a study of the effects of short-term (2 wk) and long-term (8 wk) administration of imipramine on the expression of ce...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Brady, L S, Whitfield, H J, Fox, R J, Gold, P W, Herkenham, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329870/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1671867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115086
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