Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans

Mutations in WNK1 and WNK4 cause familial hypertension, the Gordon syndrome. WNK1 and WNK4 conserved noncoding regions were targeted to polymorphism screening using DHPLC and DGGE. The scan identified an undescribed polymorphic AluYb8 insertion in WNK1 intron 10. Screening in primates revealed that...

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Autori principali: Putku, Margus, Kepp, Katrin, Org, Elin, Sõber, Siim, Comas, David, Viigimaa, Margus, Veldre, Gudrun, Juhanson, Peeter, Hallast, Pille, Tõnisson, Neeme, Shaw-Hawkins, Sue, Caulfield, Mark J, Khusnutdinova, Elza, Kožich, Viktor, Munroe, Patricia B, Laan, Maris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2011
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298642/
https://ncbi.nlm.nih.gov/pubmed/21520334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21508
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