Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes

BACKGROUND: Japanese encephalitis virus (JEV) infection is a major cause of acute encephalopathy in children, which destroys central nervous system (CNS) cells, including astrocytes and neurons. Matrix metalloproteinase (MMP)-9 has been shown to degrade components of the basal lamina, leading to dis...

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Bibliografske podrobnosti
Main Authors: Yang, Chuen-Mao, Lin, Chih-Chung, Lee, I-Ta, Lin, Yi-Hsin, Yang, Caleb M, Chen, Wei-June, Jou, Mei-Jie, Hsiao, Li-Der
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298505/
https://ncbi.nlm.nih.gov/pubmed/22251375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-12
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