Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency.

Complementary DNAs encoding the precursor of human hepatic mitochondrial acetoacetyl-CoA thiolase (T2) (EC 2.3.1.9) were cloned and sequenced. The cDNA inserts in these clones were 1,518 bases in length when overlapped, and encoded the 427-amino acid precursor of this enzyme (45,199 mol wt). This am...

Full description

Saved in:
Bibliographic Details
Main Authors: Fukao, T, Yamaguchi, S, Kano, M, Orii, T, Fujiki, Y, Osumi, T, Hashimoto, T
Format: Artigo
Language:Inglês
Published: 1990
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC329848/
https://ncbi.nlm.nih.gov/pubmed/1979337
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items