Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background

PURPOSE: Mutations in destrin (Dstn) cause corneal abnormalities in mice. A null mutation, Dstn(corn1), results in corneal epithelial hyperproliferation, inflammation, and neovascularization in the A.BY background (A.BY Dstn(corn1)). Homozygosity for a point mutation, Dstn(corn1–2J), results in mild...

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Main Authors: Kawakami-Schulz, Sharolyn V., Verdoni, Angela M., Sattler, Shannon G., Ikeda, Akihiro, Ikeda, Sakae
Format: Artigo
Language:Inglês
Published: Molecular Vision 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298451/
https://ncbi.nlm.nih.gov/pubmed/22419854
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