Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by non-integrating plasmid expression

The utility of induced pluripotent stem cells (iPSCs) as models to study diseases and as sources for cell therapy depends on the integrity of their genomes. Despite recent publications of DNA sequence variations in the iPSCs, the true scope of such changes for the entire genome is not clear. Here we...

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Autors principals: Cheng, Linzhao, Hansen, Nancy F., Zhao, Ling, Du, Yutao, Zou, Chunlin, Donovan, Frank X., Chou, Bin-Kuan, Zhou, Guangyu, Li, Shijie, Dowey, Sarah N., Ye, Zhaohui, Chandrasekharappa, Settara C., Yang, Huanming, Mullikin, James C., Liu, P. Paul
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298448/
https://ncbi.nlm.nih.gov/pubmed/22385660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.01.005
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