Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.

We have developed a murine model of wasting by injecting intracerebrally cells which continuously secrete h-cachectin/TNF (CHO-TNF) to: (a) determine the effects of cachectin/TNF produced continuously in the central nervous system (CNS), and (b) compare the metabolic effects of cachectin/TNF-secreti...

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Pubblicato in:	J Clin Invest
Autori principali:	Tracey, K J, Morgello, S, Koplin, B, Fahey, T J, Fox, J, Aledo, A, Manogue, K R, Cerami, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329839/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2254457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114937
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