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Dose-Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity
INTRODUCTION: Sulfobutylether-β-cyclodextrin (SBE-CD) is a pharmaceutical excipient known to bind verapamil. Following intravenous administration, clearance of SBE-CD approximates glomerular filtration rate. We hypothesized that infusion of SBE-CD would increase time to asystole in a rat model of ve...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Department of Emergency Medicine, University of California, Irvine
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3298207/ https://ncbi.nlm.nih.gov/pubmed/22461924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5811/westjem.2011.3.6696 |
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