A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

Surface-exposed calreticulin (ecto-CRT) and secreted ATP are crucial damage-associated molecular patterns (DAMPs) for immunogenic apoptosis. Inducers of immunogenic apoptosis rely on an endoplasmic reticulum (ER)-based (reactive oxygen species (ROS)-regulated) pathway for ecto-CRT induction, but the...

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Main Authors: Garg, Abhishek D, Krysko, Dmitri V, Verfaillie, Tom, Kaczmarek, Agnieszka, Ferreira, Gabriela B, Marysael, Thierry, Rubio, Noemi, Firczuk, Malgorzata, Mathieu, Chantal, Roebroek, Anton J M, Annaert, Wim, Golab, Jakub, de Witte, Peter, Vandenabeele, Peter, Agostinis, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298003/
https://ncbi.nlm.nih.gov/pubmed/22252128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.497
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