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Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat.

These studies test the hypothesis that a major determinant of excessive biliary cholesterol secretion is a level of hepatic sterol synthesis that is inappropriately high relative to the needs of the liver cell for preserving cholesterol balance. Biliary cholesterol secretion was measured in vivo in...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Bilhartz, L E, Spady, D K, Dietschy, J M
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1989
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329776/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2794055/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114283
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