Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor

[Image: see text] A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets protease-activated receptor 1 (PAR1). We now report additional str...

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Detalhes bibliográficos
Main Authors: Dockendorff, Chris, Aisiku, Omozuanvbo, VerPlank, Lynn, Dilks, James R., Smith, Daniel A., Gunnink, Susanna F., Dowal, Louisa, Negri, Joseph, Palmer, Michelle, MacPherson, Lawrence, Schreiber, Stuart L., Flaumenhaft, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297361/
https://ncbi.nlm.nih.gov/pubmed/22408714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2002696
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