Novel Marine Phenazines as Potential Cancer Chemopreventive and Anti-Inflammatory Agents

Two new (1 and 2) and one known phenazine derivative (lavanducyanin, 3) were isolated and identified from the fermentation broth of a marine-derived Streptomyces sp. (strain CNS284). In mammalian cell culture studies, compounds 1, 2 and 3 inhibited TNF-α-induced NFκB activity (IC(50) values of 4.1,...

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Main Authors: Kondratyuk, Tamara P., Park, Eun-Jung, Yu, Rui, van Breemen, Richard B., Asolkar, Ratnakar N., Murphy, Brian T., Fenical, William, Pezzuto, John M.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297008/
https://ncbi.nlm.nih.gov/pubmed/22412812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md10020451
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