Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts.

Three lines of investigation indicated that hydrogen peroxide (H2O2) from xanthine oxidase (XO) contributes to cardiac dysfunction during reperfusion after ischemia. First, addition of dimethylthiourea (DMTU), a highly permeant O2 metabolite scavenger (but not urea) simultaneously with reperfusion i...

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Bibliographic Details
Main Authors: Brown, J M, Terada, L S, Grosso, M A, Whitmann, G J, Velasco, S E, Patt, A, Harken, A H, Repine, J E
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC329662/
https://ncbi.nlm.nih.gov/pubmed/3127425
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