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Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking

The orexin / hypocretin system is involved in several addiction-related behaviors. The present experiments examined the involvement of orexin in heroin reinforcement and relapse by administering the orexin 1 receptor antagonist SB-334867 prior to heroin self-administration or prior to cue- or heroin...

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Detalhes bibliográficos
Main Authors: Smith, Rachel J., Aston-Jones, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295925/
https://ncbi.nlm.nih.gov/pubmed/22356621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2012.08013.x
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