Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity.

We have developed a method to isolate insulin-responsive human hepatocytes from an intraoperative liver biopsy to study insulin action and resistance in man. Hepatocytes from obese patients with noninsulin-dependent diabetes were resistant to maximal insulin concentration, and those from obese contr...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Caro, J F, Ittoop, O, Pories, W J, Meelheim, D, Flickinger, E G, Thomas, F, Jenquin, M, Silverman, J F, Khazanie, P G, Sinha, M K
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 1986
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329556/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3522628/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112558
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