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Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types
The unprecedented genetic diversity found at vertebrate MHC (major histocompatibility complex) loci influences susceptibility to most infectious and autoimmune diseases. The evolutionary explanation for how these polymorphisms are maintained has been controversial. One leading explanation, antagonis...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3295311/ https://ncbi.nlm.nih.gov/pubmed/22323587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112633109 |
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