Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types

The unprecedented genetic diversity found at vertebrate MHC (major histocompatibility complex) loci influences susceptibility to most infectious and autoimmune diseases. The evolutionary explanation for how these polymorphisms are maintained has been controversial. One leading explanation, antagonis...

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Bibliographic Details
Main Authors: Kubinak, Jason L., Ruff, James S., Hyzer, Cornelius Whitney, Slev, Patricia R., Potts, Wayne K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295311/
https://ncbi.nlm.nih.gov/pubmed/22323587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112633109
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