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Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats

Clinical data and experimental studies in rats have shown that the aged CNS is more susceptible to the proconvulsive effects of the excitotoxic glutamate analogues kainate (KA) and domoate (DA), which bind high-affinity receptors localized at mossy fiber (MF) synapses in the CA3 subregion of the hip...

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Bibliografiske detaljer
Main Authors: Kanak, Daniel J., Jones, Ryan T., Tokhi, Ashish, Willingham, Amy L., Zaveri, Hitten P., Rose, Gregory M., Patrylo, Peter R.
Format: Artigo
Sprog:Inglês
Udgivet: JKL International LLC 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295070/
https://ncbi.nlm.nih.gov/pubmed/22396884
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