Ocular Distribution, Spectrum of Activity, and In Vivo Viral Neutralization of a Fully Humanized Anti-Herpes Simplex Virus IgG Fab Fragment following Topical Application

Herpes simplex ocular infection is a major cause of corneal blindness. Local antiviral treatments exist but are associated with corneal toxicity, and resistance has become an issue. We evaluated the biodistribution and efficacy of a humanized anti-herpes simplex virus (anti-HSV) IgG FAb fragment (AC...

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Autori principali: Berdugo, Marianne, Larsen, Inna V., Abadie, Claire, Deloche, Catherine, Kowalczuk, Laura, Touchard, Elodie, Dubielzig, Richard, Brandt, Curtis R., Behar-Cohen, Francine, Combette, Jean-Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294958/
https://ncbi.nlm.nih.gov/pubmed/22203590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05145-11
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