Frequentist and Bayesian Pharmacometric-Based Approaches To Facilitate Critically Needed New Antibiotic Development: Overcoming Lies, Damn Lies, and Statistics

Antimicrobial drug development has greatly diminished due to regulatory uncertainty about the magnitude of the antibiotic treatment effect. Herein we evaluate the utility of pharmacometric-based analyses for determining the magnitude of the treatment effect. Frequentist and Bayesian pharmacometric-b...

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Main Authors: Ambrose, Paul G., Hammel, Jeffrey P., Bhavnani, Sujata M., Rubino, Christopher M., Ellis-Grosse, Evelyn J., Drusano, George L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294956/
https://ncbi.nlm.nih.gov/pubmed/22155834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01743-10
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