Identification of a Cryptococcus neoformans Cytochrome P450 Lanosterol 14α-Demethylase (Erg11) Residue Critical for Differential Susceptibility between Fluconazole/Voriconazole and Itraconazole/Posaconazole

Cryptococcus neoformans strains resistant to azoles due to mutations causing alterations in the ERG11 gene, encoding lanosterol 14α-demethylase, have rarely been reported. In this study, we have characterized a C. neoformans serotype A strain that is resistant to high concentrations of fluconazole (...

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Main Authors: Sionov, Edward, Chang, Yun C., Garraffo, H. Martin, Dolan, Michael A., Ghannoum, Mahmoud A., Kwon-Chung, Kyung J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294891/
https://ncbi.nlm.nih.gov/pubmed/22155829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05502-11
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