Mucosal Immunization with an Unadjuvanted Vaccine That Targets Streptococcus pneumoniae PspA to Human Fcγ Receptor Type I Protects against Pneumococcal Infection through Complement- and Lactoferrin-Mediated Bactericidal Activity

Targeting an antigen to Fc receptors (FcR) can enhance the immune response to the antigen in the absence of adjuvant. Furthermore, we recently demonstrated that intranasal immunization with an FcγR-targeted antigen enhances protection against a category A intracellular mucosal pathogen, Francisella...

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Auteurs principaux: Bitsaktsis, Constantine, Iglesias, Bibiana V., Li, Ying, Colino, Jesus, Snapper, Clifford M., Hollingshead, Susan K., Pham, Giang, Gosselin, Diane R., Gosselin, Edmund J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Microbial Immunity and Vaccines
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294663/
https://ncbi.nlm.nih.gov/pubmed/22158740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05511-11
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