Vaccination of BALB/c Mice with an Avirulent Mycoplasma pneumoniae P30 Mutant Results in Disease Exacerbation upon Challenge with a Virulent Strain

Mycoplasma pneumoniae is a significant human respiratory pathogen that causes high morbidity worldwide. No vaccine to prevent M. pneumoniae infection currently exists, since the mechanisms of pathogenesis are poorly understood. To this end, we constructed a P30 cytadhesin mutant (P-130) with a drast...

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Главные авторы: Szczepanek, S. M., Majumder, S., Sheppard, E. S., Liao, X., Rood, D., Tulman, E. R., Wyand, S., Krause, D. C., Silbart, L. K., Geary, S. J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2012
Предметы:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294651/
https://ncbi.nlm.nih.gov/pubmed/22252865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06078-11
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