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Hyperglycemia and Renin-Dependent Hypertension Synergize to Model Diabetic Nephropathy

Rodent models exhibit only the earliest features of human diabetic nephropathy, which limits our ability to investigate new therapies. Hypertension is a prerequisite for advanced diabetic nephropathy in humans, so its rarity in typical rodent models may partly explain their resistance to nephropathy...

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Detalles Bibliográficos
Main Authors: Conway, Bryan R., Rennie, Jillian, Bailey, Matthew A., Dunbar, Donald R., Manning, Jonathan R., Bellamy, Christopher O., Hughes, Jeremy, Mullins, John J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294297/
https://ncbi.nlm.nih.gov/pubmed/22193383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011060577
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