Direct Sorting of the Yeast Uracil Permease to the Endosomal System Is Controlled by Uracil Binding and Rsp5p-dependent Ubiquitylation

The yeast uracil permease, Fur4p, is downregulated by uracil, which is toxic to cells with high permease activity. Uracil promotes cell surface Rsp5p-dependent ubiquitylation of the permease, signaling its endocytosis and further vacuolar degradation. We show here that uracil also triggers the direc...

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Main Authors: Blondel, Marie-Odile, Morvan, Joëlle, Dupré, Sophie, Urban-Grimal, Danièle, Haguenauer-Tsapis, Rosine, Volland, Christiane
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2004
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC329401/
https://ncbi.nlm.nih.gov/pubmed/14657252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-04-0202
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