Calcium-Sensing Receptor and Aquaporin 2 Interplay in Hypercalciuria-Associated Renal Concentrating Defect in Humans. An In Vivo and In Vitro Study

One mechanism proposed for reducing the risk of calcium renal stones is activation of the calcium-sensing receptor (CaR) on the apical membranes of collecting duct principal cells by high luminal calcium. This would reduce the abundance of aquaporin-2 (AQP2) and in turn the rate of water reabsorptio...

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Hlavní autoři: Procino, Giuseppe, Mastrofrancesco, Lisa, Tamma, Grazia, Lasorsa, Domenica Rita, Ranieri, Marianna, Stringini, Gilda, Emma, Francesco, Svelto, Maria, Valenti, Giovanna
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293925/
https://ncbi.nlm.nih.gov/pubmed/22403735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033145
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