A Highly Sensitive Quantitative Real-Time PCR Assay for Determination of Mutant JAK2 Exon 12 Allele Burden

Mutations in the Janus kinase 2 (JAK2) gene have become an important identifier for the Philadelphia-chromosome negative chronic myeloproliferative neoplasms. In contrast to the JAK2V617F mutation, the large number of JAK2 exon 12 mutations has challenged the development of quantitative assays. We p...

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Main Authors: Kjær, Lasse, Westman, Maj, Hasselbalch Riley, Caroline, Høgdall, Estrid, Weis Bjerrum, Ole, Hasselbalch, Hans
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293922/
https://ncbi.nlm.nih.gov/pubmed/22403733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033100
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