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Critical Role of Leucine-Valine Change in Distinct Low pH Requirements for Membrane Fusion between Two Related Retrovirus Envelopes

Many viruses use a pH-dependent pathway for fusion with host cell membrane, the mechanism of which is still poorly understood. Here we report that a subtle leucine (Leu)-valine (Val) change at position 501 in the envelope glycoproteins (Envs) of two related retroviruses, jaagsiekte sheep retrovirus...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Côté, Marceline, Zheng, Yi-Min, Li, Kun, Xiang, Shi-Hua, Albritton, Lorraine M., Liu, Shan-Lu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293530/
https://ncbi.nlm.nih.gov/pubmed/22235118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334722
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