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Mutation of Glu(521) or Glu(535) in Cytoplasmic Loop 5 Causes Differential Misfolding in Multiple Domains of Multidrug and Organic Anion Transporter MRP1 (ABCC1)

The polytopic 5-domain multidrug resistance protein 1 (MRP1/ABCC1) extrudes a variety of drugs and organic anions across the plasma membrane. Four charged residues in the fifth cytoplasmic loop (CL5) connecting transmembrane helix 9 (TM9) to TM10 are critical for stable expression of MRP1 at the pla...

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Detalhes bibliográficos
Main Authors: Iram, Surtaj H., Cole, Susan P. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293527/
https://ncbi.nlm.nih.gov/pubmed/22232552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310409
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