Loss of PKCδ results in characteristics of Sjögren’s syndrome including salivary gland dysfunction

Chronic infiltration of lymphocytes into the salivary and lacrimal glands of Sjögren’s Syndrome patients leads to destruction of acinar cells and loss of exocrine function. Protein kinase C-delta (PKCδ) is known to play a critical role in B cell maintenance. Mice in which the PKCδ gene has been disr...

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Main Authors: Banninger, Gregg P., Cha, Seunghee, Said, M Sherif, Pauley, Kaleb M., Carter, Cristan J., Ornate, Mairelys, Pauley, Brad A., Anderson, Steven M., Reyland, Mary E.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293255/
https://ncbi.nlm.nih.gov/pubmed/21702866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1601-0825.2011.01819.x
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