Loss of PKCδ results in characteristics of Sjögren’s syndrome including salivary gland dysfunction

Chronic infiltration of lymphocytes into the salivary and lacrimal glands of Sjögren’s Syndrome patients leads to destruction of acinar cells and loss of exocrine function. Protein kinase C-delta (PKCδ) is known to play a critical role in B cell maintenance. Mice in which the PKCδ gene has been disr...

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Bibliographische Detailangaben
Hauptverfasser: Banninger, Gregg P., Cha, Seunghee, Said, M Sherif, Pauley, Kaleb M., Carter, Cristan J., Ornate, Mairelys, Pauley, Brad A., Anderson, Steven M., Reyland, Mary E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293255/
https://ncbi.nlm.nih.gov/pubmed/21702866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1601-0825.2011.01819.x
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