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Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

BACKGROUND: The p38α MAPK isoform is a well-established therapeutic target in peripheral inflammatory diseases, but the importance of this kinase in pathological microglial activation and detrimental inflammation in CNS disorders is less well understood. To test the role of the p38α MAPK isoform in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Xing, Bin, Bachstetter, Adam D, Van Eldik, Linda J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292986/
https://ncbi.nlm.nih.gov/pubmed/22185458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-84
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