Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells

BACKGROUND: Aneuploidy has been acknowledged as a major source of genomic instability in cancer, and it is often considered the result of chromosome segregation errors including those caused by defects in genes controlling the mitotic spindle assembly, centrosome duplication and cell-cycle checkpoin...

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Autors principals: Barra, Viviana, Schillaci, Tiziana, Lentini, Laura, Costa, Giuseppe, Di Leonardo, Aldo
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292948/
https://ncbi.nlm.nih.gov/pubmed/22305267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-7-2
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