CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo

Thus far the clinical benefits seen in breast cancer patients treated with drugs targeting the vascular endothelial growth factor (VEGF) pathway are only modest. Consequently, additional antiangiogenic approaches for treatment of breast cancer need to be investigated. Thrombospondin-2 (TSP-2) has be...

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Bibliographic Details
Main Authors: Koch, Manuel, Hussein, Fadi, Woeste, Andreas, Gründker, Carsten, Frontzek, Karl, Emons, Günter, Hawighorst, Thomas
Format: Artigo
Language:Inglês
Published: Springer US 2010
Subjects:
Preclinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291836/
https://ncbi.nlm.nih.gov/pubmed/20714802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-010-1085-7
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