Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels

Uncovering principles that regulate energy metabolism in the brain requires mapping of partial pressure of oxygen (PO(2)) and blood flow with high spatial and temporal resolution. Using two-photon phosphorescence lifetime microscopy (2PLM) and the oxygen probe PtP-C343, we show that PO(2) can be acc...

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Main Authors: Lecoq, Jérôme, Parpaleix, Alexandre, Roussakis, Emmanuel, Ducros, Mathieu, Houssen, Yannick Goulam, Vinogradov, Sergei A, Charpak, Serge
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291110/
https://ncbi.nlm.nih.gov/pubmed/21642977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2394
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