Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

AIMS: Circulating endogenous, dietary, and foreign chemicals can contribute to vascular dysfunction. The mechanism by which the vasculature protects itself from these chemicals is unknown. This study investigates whether the pregnane X receptor (PXR), the major transcriptional regulator of hepatic d...

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Hlavní autoři: Swales, Karen E., Moore, Rick, Truss, Nicola J., Tucker, Arthur, Warner, Timothy D., Negishi, Masahiko, Bishop-Bailey, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291088/
https://ncbi.nlm.nih.gov/pubmed/22166712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr330
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