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BDNF Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex
BACKGROUND: Knock-in mice with the common human BDNF Val66Met polymorphism have impaired trafficking of BDNF mRNA to dendrites. Given evidence that local synapse formation is dependent on dendritic translation of BDNF mRNA, it was hypothesized that loss-of-function Met allele mice would show synapti...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290730/ https://ncbi.nlm.nih.gov/pubmed/22036038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.09.030 |
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