Pathogenic Connexin-31 Forms Constitutively Active Hemichannels to Promote Necrotic Cell Death

Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive. We report here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic chara...

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Detaylı Bibliyografya
Asıl Yazarlar: Chi, Jingwei, Li, Li, Liu, Mujun, Tan, Jieqiong, Tang, Chengyuan, Pan, Qian, Wang, Danling, Zhang, Zhuohua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290583/
https://ncbi.nlm.nih.gov/pubmed/22393412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032531
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