Pathogenic Connexin-31 Forms Constitutively Active Hemichannels to Promote Necrotic Cell Death

Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive. We report here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic chara...

Full description

Saved in:
Bibliographic Details
Main Authors: Chi, Jingwei, Li, Li, Liu, Mujun, Tan, Jieqiong, Tang, Chengyuan, Pan, Qian, Wang, Danling, Zhang, Zhuohua
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290583/
https://ncbi.nlm.nih.gov/pubmed/22393412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032531
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items