Pathogenic Connexin-31 Forms Constitutively Active Hemichannels to Promote Necrotic Cell Death

Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive. We report here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic chara...

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Autori principali: Chi, Jingwei, Li, Li, Liu, Mujun, Tan, Jieqiong, Tang, Chengyuan, Pan, Qian, Wang, Danling, Zhang, Zhuohua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290583/
https://ncbi.nlm.nih.gov/pubmed/22393412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032531
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