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Pathogenic Connexin-31 Forms Constitutively Active Hemichannels to Promote Necrotic Cell Death
Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive. We report here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic chara...
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| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290583/ https://ncbi.nlm.nih.gov/pubmed/22393412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032531 |
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